Director Facilities

Job Locations US-CA-South San Francisco
Position Type
Regular Full-Time

About Us

Nkarta is a publicly traded (Nasdaq symbol NKTX), South San Francisco headquartered, early-stage biopharmaceutical company focused on the discovery, development and commercialization of allogeneic, off-the-shelf engineered natural killer, or NK, cell therapies to treat cancer.


Founded in 2015 at the birthplace of biotechnology, our development pipeline of engineered NK cell therapy candidates includes two co-lead clinical programs, NKX101 and NKX019. Clinical trials for 101 are in process; 019 will begin in H2 2021. Nkarta recently announced a collaboration with CRISPR Therapeutics, a world leader in gene-based medicines, for the development and commercialization of up to three new cell therapy candidates and access to clinically validated CRISPR/Cas9 genome engineering.


Complementing our broad research and development capabilities, Nkarta has also built an extensive cell therapy manufacturing operation.  We have a 2,700-square foot clinical good manufacturing practice, or cGMP, facility on-site at our primary corporate location in South San Francisco, California. We plan to start in-house manufacturing of NKX019 in 2021 and NKX101 in 2022. We are also currently designing a separate, larger cGMP facility, to supply our anticipated pivotal clinical trial and commercial needs.


This is a lead role for the Facilities engineering and operation of a new commercial manufacturing, lab and headquarters facility located in South San Francisco, CA. The Director of Engineering, Facilities will take ownership of 1150 Veterans and all its facilities and processes supporting manufacturing, labs and office.


The Director will manage the functions of the facilities and engineering and maintenance groups and will have responsibility for planned, preventative and corrective maintenance, installation and modification of equipment, machinery, and buildings systems, utilizing both internal and contract resources across multiple sites. Position will be required to manage capital projects and equipment installs to support corporate and GMP locations as directed. This position also leads compliance activities for the Facilities Engineering Organization


  • Play integral role in facilities operation and ongoing construction.
  • Plan, direct and coordinate installation, operation, maintenance and repair of GMP and non-GMP equipment.
  • Support/coordinate facility validation in partnership with Quality and Validation functions
  • Responsible for vendor management including vendor procurement, contract negotiation/execution, and management for services and other activities
  • Administer facility preventive maintenance and calibration program
  • Establish and maintain organizational procedures and controls in providing effective and timely services such as preventive and routine maintenance, equipment repair, calibration, management of building maintenance systems (BMS), and emergency repair.
  • Responsible for Engineering department and all associated policies and procedures
  • Manage and schedule retrofit and replacement of GMP and non-GMP systems


  • 10+ years of biotech/pharmaceutical engineering experience with certification in facilities management a plus.
  • 5+ years experience as facilities supervisor/engineer with full responsibility for a facility.
  • Effective interpersonal skills, project management and organizational skills.
  • Ability to develop annual and multi-year facilities operational plans and budgets in partnership with Finance.
  • Demonstrated ability to follow established procedures and maintain Documentation Systems for cGMP compliance.

Working at Nkarta Inc.

The 130+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas in which we’re working, here are real anonymous comments of why people think Nkarta is a great place to work.

  • People are always open to ideas. This company provides a safe place for its employees (covid testing, etc.)”
  • Exceptionally talented, committed, *kind* & supportive team”
  • The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique.”
  • Not to sound corny, but the emphasis on people as a valuable resource is something I  recognize doesn't often exist elsewhere, and it's here in ample supply, which is great.”
  • It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood.”
  • We have a very diverse team with executives that are friendly and accessible.”
  • Smart and dedicated colleagues. Mission to make a difference in patients lives. Empower us with tools needed to succeed.  Open and transparent culture. Transparent leadership. Handling of covid and running the company was done very well.”


To learn more about our work at Nkarta and the career opportunities that will drive us forward to serve patients, please visit the company’s website



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